The Mitochondrial dysfunctions have been involved in number of neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington disease and others. Certain factors like metabolic disturbance, acidosis, excitotoxicity, oxidative stress, neuro inflammation and dis regulation of mitochondrial functions are thoroughly involved.
Despite the differences in symptomatic pictures among Neurodegenerative Diseases (ND) all of them result in selective or generalized neuronal loss. The cascade of events leading to the neuronal death is multifactorial. The factors involved include metabolic disturbance, acidosis, excitotoxicity, oxidative stress, neuroinflammation, pathological aggregation of some proteins, and disregulation of mitochondrial functions.