Morphological Relationship between Nerve Fibers and Melanocytes in the Epidermis of Melasma

Posted on Updated on

A close contact between melanocytes and nerve fibers in the epidermis has been demonstrated in normal human skin. The interactions between the neural and immune systems play an important role in the pathophysiology of certain dermatoses. In this study, we investigated the intraepidermal nerve fibers and their contacts with melanocytes in the lesions of melasma using double labeled immunofluorescency and confocal laser scanning microscopy.

melanocytes

We found that the percentage of contacts between intraepidermal nerve fibers and melanocytes in the lesion of melasma were 74%, significantly more than the 42% in the normal controls (p<0.05). The percentage of melasma lesions was also more than the 69% in the normal-appearing skin of the melasma patients (p<0.05). Our results of the increased contacts between the nerve fibers and melanocytes in the lesions of melasma suggest a potential coordination between the neural and cutaneous immune systems.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s