Psoriasis is one among the autoimmune diseases, characterized by abnormal skin patches. The abnormal DNA methylation may be the reason for the pathogenesis of psoriasis. A study was conducted to investigate the methylation status of IL-12B gene in Psoriatic epidermis. The DNA was obtained from 30 uninvolved and involved individuals and compared them with 28 healthy persons as a control group. The results revealed that methylation in the promoter of IL-12B in both uninvolved and involved patients were high when compared to that of control group. From the results, it is evident that abnormal methylation in IL-12B is involved in the pathogenesis of psoriasis.