clinical dermatology research journal
Anti-Dermatophytic Potential of Formulated Extract of Cola nitida (Vent.) Schott & Endl. (Stem Bark)
The antifungal activities of stem bark ethanolic extract of Cola nitida [Vent.) Schott & Endl. against fungi associated with dermatophytes was determined in vitro by agar cup diffusion, agar dilution technique, and time kill assay. The result showed that the extract at concentrations ranging between 6 mg/mL to 0.5 mg/mL produced zone of inhibition between 10 ± 0.1 and 25 ± 0.2 mm against the test fungi. The MIC and MFC of the extract ranged from 22.5 to 3120 µg/mL and 45 to 3120 µg/mL respectively. The MICs for Trichophyton rubrum and T. tonsurans were less than 100 µg/mL and the mechanism of antibiosis indicated that the formulated ethanolic extract was highly fungicidal. Since lower MIC and MFC indicates higher efficacy, the MIC/MFC in this study are within the range of ≤ 100 and ≥ 1000 µg/mL.
The term erythrokeratodermia is applied to a group of inherited disorders of keratinisation characterized by well demarcated erythematous lesions and hyperkeratotic plaques. Erythrokeratoderma en cocardes is an atypical variant characterised by the presence of transient hyperkeratotic and erythematous plaques. The pathogenetic mechanisms of most of the erythrokeratodermia are related to mutations in the connexin gene family, but until now, there is no information concerning the genetic alterations that are responsible for the appearance of the erythrokeratoderma en cocardes. We report the case of a 31-year-old woman with a 5-year history of fixed erythematous plaques with scaly rims on the arms, trunk, axillae and limb flexures that disappeared spontaneously and recurred every summer.
Oral Manifestations of Pemphigus Vulgaris: Clinical Presentation, Differential Diagnosis and Management
Pemphigus vulgaris is a chronic autoimmune mucocutaneous disease characterized by the formation of intraepithelial blisters. It results from an autoimmune process in which antibodies are produced against desmoglein 1 and desmoglein 3, normal components of the cell membrane of keratinocytes. The first manifestations of pemphigus vulgaris appear in the oral mucosa in the majority of patients, followed at a later date by cutaneous lesions. The diagnosis is based on clinical findings and laboratory analyses, and it is usually treated by the combined administration of corticosteroids and immunosuppressants. Detection of the oral lesions can result in an earlier diagnosis. We review the oral manifestations of pemphigus vulgaris as well as the differential diagnosis, treatment, and prognosis of oral lesions in this uncommon disease.