nanotechnology impact factor
Multifunctional Nanoplatform for Targeted Laser-induced Hyperthermia and Microscopy of Breast Cancer Cells using SPION-based Gold and Folic Acid Conjugated Nano dendrimers: An in vitro Assay
The use of nanotechnology seems to be a promising approach for early detection, imaging and therapy of cancer. In this investigation, 9 nm superparamagnetic iron oxide nanoparticles (SPION) were synthesized and functionalized by third generation polyamidoamine (G3-PAMAM) dendrimer. The magneto dendrimer samples were then conjugated by folic acid molecules for targeting and by gold nanoparticles for photothermal hyperthermia purpose. The gold nanoparticles were synthesized using three reducing agents of sodium borohydride, hydrazine sulfate and pre synthesized 10-nm AuNPs.
The final nanocomposite is named IDAF NC (Iron oxide-Dendrimer-Gold-Folic acid). Two breast cancer cell lines of MDA MB 231 and MCF 7 were used for cytotoxicity, uptake and photothermal assay. The results confirmed that AuNPs prepared by sodium borohydride and the pre-synthesized 10-nm AuNPs were larger and those prepared by hydrazine sulfate were smaller and uniformly entrapped within dendrimer cavities. The MDA MB 231-IDAF-Hydr combination exhibited the highest viability percentage at 50 μg/mL before laser irradiation and lowest cancer cell viability of 65% (i.e., highest cell apoptosis and crystallization after irradiation).
Valued for ZnO ultra violet absorbance, wide chemistry, piezoelectricity and luminescence at high temperatures, ZnO has penetrated far into industry, and is one of the critical buildings in today modern society. ZnO is indeed a key element in many industrial manufacturing processes including paints, cosmetics, pharmaceuticals, plastic, batteries, electrical equipment, rubber, soap, textile, floor covering etc. with improvement in growth technology of ZnO nanostructures, single crystal and nanoparticles, ZnO devices will become increasing functional in the near future. Metal oxide nanoparticles were extensively investigated due to their applications in the field of spintronics, photoelectronic, sensor, lasing devices and light emitting diodes, etc. The properties of these nanomaterials incredibly altered due to quantum confinement and enhanced surface to volume ratio. ZnO is a multifunctional material. The piezo-electric and pyroelectric properties of ZnO mean that it can be used as a sensor, converter, energy generator and photo catalyst in hydrogen production.
A simple and sensitive, HPTLC method has been developed for the quantitative estimation of metformin in its single component tablet formulation. Metformin was chromatographed on silica Gel 60 F 254 TLC plate using ammonium sulfate (0.5%): 2-propanol: methanol in the ratio of 8.0:1.6:1.6 (v/v/v) as mobile phase.
Metformin showed R f value of 0.50±0.03 was scanned at 238 nm using Camag TLC Scanner 3. The linear regression data for the calibration plot showed a good relationship with r =0.999. The method was validated for precision and recovery. The limits of detection and quanti fi cation were 95 and 200 ng/spot respectively. The developed method was successfully used for the assay of metformin tablet formulations. The method is simple, sensitive and precise; it can be used for the routine quality control testing of marketed formulations.
Endodontic as a field of dentistry has made giant leaps in the past two to three decades. Designs and techniques for instrumentation and observation of the root canal systems. Contrary to this ascent in endodontic material, the foremost factors that have repeatedly been documented to significantly impact the outcome of primary root canal treatment are pre-operative pulpal and periapical status; An accurate clinical diagnosis of the pulpal condition could possibly enable managing initial irreversible pulpitis with vital pulp therapy instead of the radical devitalisation approach of root canal treatment.
While simultaneously enhancing operator efficiency in performing traditional endodontics. Restorative Dentistry evolved as a recognised speciality in 1973 and in the United Kingdom it is legally recognized as a specialty under European Union directive. In the future, further significant changes within health care systems and the increasing needs of the population with will see an increasing demand and need for Restorative Dentistry services.
Rehabilitation is the process of restoring and regaining physical strength and function. Rehabilitation includes various therapies to help a person restore function after illness or injury. It describes specialized healthcare dedicated to improving, maintaining or restoring physical strength, cognition and mobility with maximized results. Typically, rehabilitation helps people gain greater independence after illness, injury or surgery