The Use of Sulfasalazine in Severe Types of Alopecia Areata

Extensive types of alopecia areata (AA), especially alopecia totalis (AT) and alopecia universalis (AU) are notoriously difficult to treat. Recently, sulfasalazine has shown a promising result with well-tolerated side effects through Immuno modulatory and anti-inflammatory effects. Several studies reported desirable response among AA patients who failed other treatments. This article reviews the previous studies of sulfasalazine in AA in terms of its efficacy as well as other aspects including mode of action, indications, contraindications, dosage, administration, drug interaction as well as monitoring.

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